Anti-inflammatory Effect of Methanol Extract from Safflower Seeds

Periodontitis is an inflammatory disease, which destroys the connective tissue and the alveolar bone. Recently, it has been suggested that the effect of natural substances could be induced into an anti-inflammatory environment. However, the effect of Safflower seed extract (SAF-M) associated with periodontitis has not been investigated yet. Therefore, the purpose of this study was to assess the anti-inflammatory effects of SAF-M. Cytotoxicity was assessed through MTS analysis using hGF and hPDL cells. Periodontitis was induced by injecting LPS into gingival tissue on the maxillary molars of rats (45 µg LPS/one time, 3 times a week for 3 weeks). SAF-M was administered daily at 30 mg/kg and 100 mg/kg. Alveolar bone resorption was evaluated through the micro-CT. hGF and hPDL cells showed differential cytotoxicity in response to SAF-M at 5 mg/ml and 1 mg/ml concentrations. Micro-CT showed reduction of the alveolar bone resorption in the SAF-M treatment group. These results suggested that SAF-M is a potential therapeutic agent for periodontitis.

A Case of Foreign Body Granuloma Caused by Injection of Safflower Seed Extracts / 대한피부과학회지

Foreign body granuloma is a chronic, proliferative, inflammatory reaction caused by persistent poorly biodegradable tissue irritants. Currently, many injectable materials are being used extensively for soft tissue augmentation. Although considered biologically inert, these materials can evoke adverse reactions such as foreign body granuloma. Mainly these complications are a result of the use of unproven products injected by unlicensed or unqualified practitioners. Here we report a case of foreign body granuloma in the left lower eyelid secondary to injection of extracts from safflower seeds.